Attempts to detect virus-specific DNA sequences in human tumors. III. Epstein-Barr viral DNA in non-lymphoid nasopharyngeal carcinoma cells

URN to cite this document:

urn:nbn:de:bvb:355-epub-207728 Copy

Wolf, Hans J. ; zur Hausen, H. ; Klein, G. ; Becker, V. ; Henle, G. ; Henle, W.

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Date of publication of this fulltext: 05 May 2011 06:35

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Details

Item type:	Article
Journal or Publication Title:	Medical microbiology and immunology
Publisher:	Springer
Volume:	161
Number of Issue or Book Chapter:	1
Page Range:	pp. 15-21
Date:	1975
Institutions:	Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:	Value Type 165392 PubMed ID
Classification:	Notation Type Carcinoma/microbiology MESH Carcinoma, Squamous Cell/microbiology MESH DNA, Neoplasm/isolation & purification MESH DNA, Viral/isolation & purification MESH Herpesvirus 4, Human/isolation & purification MESH Humans MESH Hybridization, Genetic MESH Nasopharyngeal Neoplasms/pathology MESH Nucleic Acid Hybridization MESH RNA, Neoplasm/isolation & purification MESH
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Unknown
Created at the University of Regensburg:	Unknown
Item ID:	20772

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Abstract

Fourteen tumors of the nasopharyngeal region were analyzed for the presence of Epstein-Barr virus-specific DNA by DNA-cRNA hybridization. These data were compared to the histology of the respective tumors and the seroreactivity of the tumor-bearing patient against EBV-related antigens. With one exception, all tumor pieces containing nasopharyngeal carcinoma cells hybridized significantly with ...

Abstract

Fourteen tumors of the nasopharyngeal region were analyzed for the presence of Epstein-Barr virus-specific DNA by DNA-cRNA hybridization. These data were compared to the histology of the respective tumors and the seroreactivity of the tumor-bearing patient against EBV-related antigens. With one exception, all tumor pieces containing nasopharyngeal carcinoma cells hybridized significantly with EBV-cRNA. Tumors of predominantly epithelial morphology annealed in the highest range. In situ-hybridization of freeze sections from a tumor containing almost equal amounts of tumor cells and lymphocytes revealed hybridizing DNA within nuclei of non-lymphoid cells. Although these data do not exclude the presence of EBV-DNA within lymphoid cells, they clearly demonstrate that in nasopharyngeal carcinomas the vast majority of EBV-specific DNA rests within non-lymphoid cells.

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Metadata last modified: 03 Jun 2018 04:27

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