Surfactant bolus instillation: effects of different doses on blood pressure and cerebral blood flow velocities

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urn:nbn:de:bvb:355-epub-208015 Copy

Rey, M. ; Segerer, Hugo ; Kiessling, C. ; Obladen, Michael

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Date of publication of this fulltext: 18 May 2011 08:56

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Details

Item type:	Article
Journal or Publication Title:	Biology of the neonate
Publisher:	Karger
Volume:	66
Number of Issue or Book Chapter:	1
Page Range:	pp. 16-21
Date:	1994
Institutions:	Medicine > Lehrstuhl für Kinder- und Jugendmedizin
Identification Number:	Value Type 7948436 PubMed ID
Classification:	Notation Type Blood Flow Velocity/drug effects MESH Blood Pressure/drug effects MESH Cerebrovascular Circulation/drug effects MESH Dose-Response Relationship, Drug MESH Female MESH Humans MESH Infant, Newborn MESH Male MESH Pulmonary Surfactants/therapeutic use MESH Respiratory Distress Syndrome, Newborn/drug therapy MESH
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Unknown
Created at the University of Regensburg:	Unknown
Item ID:	20801

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Abstract

Fifteen preterm infants suffering from respiratory distress syndrome were randomly allocated to receive either high-dose (200 mg/kg) or low-dose (100 mg/kg) surfactant treatment. Retreatments were done with the low dose. Blood pressure, blood gases and cerebral blood flow velocities were determined before and after 24 bolus instillations. With the high dose mean blood pressure and mean cerebral ...

Abstract

Fifteen preterm infants suffering from respiratory distress syndrome were randomly allocated to receive either high-dose (200 mg/kg) or low-dose (100 mg/kg) surfactant treatment. Retreatments were done with the low dose. Blood pressure, blood gases and cerebral blood flow velocities were determined before and after 24 bolus instillations. With the high dose mean blood pressure and mean cerebral blood flow velocity dropped significantly. With the low dose only mean cerebral blood flow velocity decreased; the course was unrelated to blood pressure or PCO2 fluctuations. The mechanisms leading to the observed circulatory changes after surfactant instillation remain unclear.

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