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Reinigung und funktionelle Charakterisierung eines rekombinanten Maus-TNF-Inhibitors
Pausch, Markus J. (2011) Reinigung und funktionelle Charakterisierung eines rekombinanten Maus-TNF-Inhibitors. PhD, Universität Regensburg.Date of publication of this fulltext: 15 Jun 2011 06:28
Thesis of the University of Regensburg
DOI to cite this document: 10.5283/epub.21074
Abstract (German)
TNF und seine Rezeptoren p75TNFR und p55TNFR spielen im Rahmen von Entzündungen und Autoimmunerkrankungen eine zentrale Rolle. Eine gezielte Hemmung von TNF wird bei Autoimmunerkrankungen, wie z.B. rheumatoider Arthritis eingesetzt. In der Arbeit wurde ein rekombinanter TNF-Inhibitor hergestellt, sowie dessen Struktur und biologische Wirksamkeit untersucht.
Translation of the abstract (English)
TNF and its receptors p75TNFR and p55TNFR play a central role in the context of inflammation and autoimmune diseases. A targeted inhibition of TNF is used in autoimmune diseases such as rheumatoid arthritis. In this study a recombinant TNF-inhibitor was prepared and its structure and biological activity examined.
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Details
| Item type | Thesis of the University of Regensburg (PhD) |
| Open Access Type: | Primary Publication |
|---|---|
| Date | 15 June 2011 |
| Referee | Prof. Dr. Daniela N. Männel and Prof. Dr. Bernd Salzberger |
| Date of exam | 27 May 2011 |
| Institutions | Medicine > Lehrstuhl für Immunologie |
| Keywords | Entzündung, Autoimmunerkrankung, p75TNFR, TNF, maus-TNF-Inhibitor, anti-TNF-Medikation, Biologicals, inflammation, autoimmune disease, p75TNFR, TNF, mouse-TNF-Inhibitor, anti-TNF-Medication, Biologicals |
| Dewey Decimal Classification | 600 Technology > 610 Medical sciences Medicine |
| Status | Published |
| Refereed | Yes, this version has been refereed |
| Created at the University of Regensburg | Yes |
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-210749 |
| Item ID | 21074 |
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