Das metastasierende differenzierte Schilddrüsenkarzinom. Diagnostische Treffsicherheit des Thyreoglobulin-RIA im Vergleich zur 13'J-Ganzkörperszintigraphie = Metastatic differentiated thyroid cancer. Diagnostic accuracy of thyroglobulin-RIA in comparison with 131I-whole body scintigraphy

URN to cite this document:

urn:nbn:de:bvb:355-epub-211183 Copy

DOI to cite this document:

10.5283/epub.21118 Copy

Reiners, C. ; Reimann, J. ; Schäffer, R. ; Baum, K. ; Becker, W. ; Eilles, Christoph ; Gerhards, W. ; Schick, F. ; Spiegel, W. ; Wiedemann, W.

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Date of publication of this fulltext: 10 Jun 2011 07:32

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Details

Item type:	Article
Journal or Publication Title:	RöFo: Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Publisher:	Thieme
Volume:	141
Number of Issue or Book Chapter:	3
Page Range:	pp. 306-313
Date:	1984
Institutions:	Medicine > Abteilung für Nuklearmedizin
Identification Number:	Value Type 6435198 PubMed ID 10.1055/s-2008-1053138 DOI
Classification:	Notation Type Adenocarcinoma/radionuclide imaging MESH Adult MESH Aged MESH Bone Neoplasms/secondary MESH Carcinoma/radionuclide imaging MESH Carcinoma, Papillary/radionuclide imaging MESH Female MESH Humans MESH Iodine Radioisotopes/diagnostic use MESH Lung Neoplasms/secondary MESH Male MESH Middle Aged MESH Neoplasm Metastasis/radionuclide imaging MESH Radioimmunoassay MESH Thyroglobulin/blood MESH Thyroid Neoplasms/radionuclide imaging MESH
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	21118

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Abstract

In a retrospective analysis in patients with differentiated thyroid carcinoma, the diagnostic validities of 131I whole-body scans and radioimmunologic determinations of thyroglobulin (hTg) are compared with special regard to late metastases. Metastases were found in 83 out of 311 patients with differentiated thyroid carcinoma. In two thirds of the cases, these were primary metastases while in the ...

Abstract

In a retrospective analysis in patients with differentiated thyroid carcinoma, the diagnostic validities of 131I whole-body scans and radioimmunologic determinations of thyroglobulin (hTg) are compared with special regard to late metastases. Metastases were found in 83 out of 311 patients with differentiated thyroid carcinoma. In two thirds of the cases, these were primary metastases while in the remaining third of the cases, metastases developed in later follow-up with a mean time of latency of 3.3 years. While about 70% of the early metastases could bei detected by 131I scintigraphy, this percentage amounted to only 40% in late metastases. With a diagnostic sensitivity of 90%, hTg-RIA was clearly superior in the detection of early as well as of late metastases. hTg was measurable, however, only in iatrogenous hypothyroidism in 4 out of 49 cases. Based on these results and an analysis of the literature, a program for follow-up of differentiated thyroid carcinoma is proposed. The hTg-RIA is thereby used as an alternative to 131I scintigraphy in the late phase of follow-up after complete ablation of any thyroid tissue.

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