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The Skin: An Immunoreactive Target Organ during Interleukin-2 Administration

Dummer, R. ; Miller, K. ; Eilles, Christoph ; Burg, G.


Six patients with metastatic malignant melanoma were treated systemically with dacarbazine and interleu-kin-2 (IL-2). During IL-2 administration all patients developed a macular erythematousrash followed by scaling which began 24–48 h after IL-2 infusion. The dermatological changes were associated with elevated interferon-γ and tumor necrosis factor α serum levels (immunoradiometric assay). ...


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