Characterization of monocyte-activating tumour cell membrane structures

URN to cite this document:: urn:nbn:de:bvb:355-epub-211569
DOI to cite this document:: 10.5283/epub.21156

Westenfelder, U. ; Schraven, B. ; Männel, Daniela N.

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Date of publication of this fulltext: 17 Jun 2011 06:11

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Abstract

Tumor cells are known to activate monocytes/macrophages and it has been shown that this stimulation was conferred by tumour-cell membranes. In order to analyse the relevant structures for tumor cell-specific TNF-induction monocytes from healthy donors were cultured in the presence of plasma membrane preparations from Jurkat or K562 cells. Both tumour cell lines revealed a monocyte-stimulating ...