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Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells

URN to cite this document:
urn:nbn:de:bvb:355-epub-211606
Schreck, R. ; Meier, B. ; Männel, D.N. ; Dröge, W. ; Baeuerle, P. A.
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Date of publication of this fulltext: 17 Jun 2011 06:08


Abstract

Dithiocarbamates and iron chelators were recently considered for the treatment of AIDS and neurodegenerative diseases. In this study, we show that dithiocarbamates and metal chelators can potently block the activation of nuclear factor kappa B (NF-kappa B), a transcription factor involved in human immunodeficiency virus type 1 (HIV-1) expression, signaling, and immediate early gene activation ...

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