A common epitope on human tumor necrosis factor alpha and the autoantigen 'S-antigen/arrestin' induces TNF-alpha production

URN to cite this document:: urn:nbn:de:bvb:355-epub-211618
DOI to cite this document:: 10.5283/epub.21161

Stiemer, R. H. ; Westenfelder, U. ; Gausepohl, H. ; Mirshahi, M. ; Gundt, A. ; Frank, R. W. ; Männel, Daniela N.

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Date of publication of this fulltext: 17 Jun 2011 06:06

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Abstract

A common epitope on S-antigen (arrestin), a potent autoantigen inducing experimental autoimmune uveoretinitis (EAU), and on human tumor necrosis factor alpha (hTNF alpha) was revealed using two monoclonal antibodies to S-antigen which inhibit EAU induction. The minimal common sequence for monoclonal antibody recognition is GVxLxD in the S-antigen/hTNF alpha amino acid sequences. Peptides ...