Lung-restricted activation of the alveolar macrophage/monocyte system in pulmonary sarcoidosis

URN to cite this document:: urn:nbn:de:bvb:355-epub-211622
DOI to cite this document:: 10.5283/epub.21162

Müller-Quernheim, J. ; Pfeifer, S. ; Männel, Daniela N. ; Strausz, J. ; Ferlinz, R.

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Date of publication of this fulltext: 20 Jun 2011 09:15

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Abstract

An activation of T-cells that is restricted to the lung has been demonstrated in pulmonary sarcoidosis. The role of blood monocytes (MO) and alveolar macrophages (AM) in this concept of compartmentalized inflammation has not yet been evaluated. In order to elucidate this question, we measured the release of tumor necrosis factor alpha (TNF alpha) and interleukin-1 (IL-1) by peripheral blood ...