Parvoviruses are inefficient in inducing interferon-beta, tumor necrosis factor-alpha, or interleukin-6 in mammalian cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-211639
DOI to cite this document:: 10.5283/epub.21163

Schlehofer, J. R. ; Rentrop, M. ; Männel, Daniela N.

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Date of publication of this fulltext: 17 Jun 2011 06:03

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Abstract

To investigate a possible role of cytokines in parvovirus-mediated suppression of tumorigenesis, we tested in cell culture whether parvoviruses are able to induce interferon (IFN)-beta, tumor necrosis factor (TNF)-alpha or interleukin-6 (IL-6). Infection of rodent or human cells with the parvoviruses minute virus of mice (MVM), H-1 or adeno-associated virus (AAV) types 2 or 5 failed to induce ...