Cytokine induction by immunomodulatory epitopes in S-antigen and tumor necrosis factor alpha

URN to cite this document:: urn:nbn:de:bvb:355-epub-211649

Stiemer, R. H. ; Westenfelder, U. ; de Kozak, Y. ; Gausepohl, H. ; Mirshahi, M. ; Frank, R. W. ; Faure, J. P. ; Männel, Daniela N.

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Date of publication of this fulltext: 17 Jun 2011 06:01

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Abstract

Common epitopes on S-antigen (arrestin), a potent autoantigen inducing experimental autoimmune uveoretinitis (EAU), and on human tumor necrosis factor alpha (hTNF alpha) are revealed with monoclonal antibodies (mAb) to S-antigen, which inhibit EAU induction. The minimal common sequence for mAb recognition is GVxLxD in the S-antigen/hTNF alpha amino acid (aa) sequences. Peptides containing this ...