Induction of tumor necrosis factor expression by a lectin from Viscum album

URN to cite this document:: urn:nbn:de:bvb:355-epub-211674
DOI to cite this document:: 10.5283/epub.21167

Männel, Daniela N. ; Becker, H. ; Gundt, A. ; Kist, A. ; Franz, H.

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Date of publication of this fulltext: 20 Jun 2011 06:16

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Abstract

A purified lectin (MLI) from Viscum album was used to test whether peripheral monocytes from human blood can be activated for the production of tumour necrosis factor (TNF). Cytotoxic activity was detected in the supernatant of MLI-stimulated monocyte cultures. This cytotoxic activity was completely inhibited by monoclonal antibodies to TNF alpha. Small amounts of soluble TNF protein were ...