Tumour necrosis factor production and natural killer cell activity in peripheral blood during treatment with recombinant tumour necrosis factor

URN to cite this document:: urn:nbn:de:bvb:355-epub-211754
DOI to cite this document:: 10.5283/epub.21175

Männel, Daniela N. ; Kist, A. ; Ho, A. D. ; Räth, U. ; Reichardt, P. ; Wiedenmann, B. ; Schlick, E. ; Kirchner, H.

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Date of publication of this fulltext: 20 Jun 2011 06:24

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Abstract

Tumour necrosis factor (TNF) has been found to be an important immunomodulator. Among other functions TNF activates natural killer (NK) cells and stimulates monocytes/macrophages in an autocrine fashion. TNF production and NK activity in peripheral blood mononuclear cells were determined in a clinical phase I study in which recombinant human (rh) TNF was administered as a continuous infusion ...