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Tumour necrosis factor production and natural killer cell activity in peripheral blood during treatment with recombinant tumour necrosis factor

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Männel, Daniela N. ; Kist, A. ; Ho, A. D. ; Räth, U. ; Reichardt, P. ; Wiedenmann, B. ; Schlick, E. ; Kirchner, H.
Date of publication of this fulltext: 20 Jun 2011 06:24


Tumour necrosis factor (TNF) has been found to be an important immunomodulator. Among other functions TNF activates natural killer (NK) cells and stimulates monocytes/macrophages in an autocrine fashion. TNF production and NK activity in peripheral blood mononuclear cells were determined in a clinical phase I study in which recombinant human (rh) TNF was administered as a continuous infusion ...


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