Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins

URN to cite this document:: urn:nbn:de:bvb:355-epub-211770
DOI to cite this document:: 10.5283/epub.21177

Flegel, W. A. ; Wölpl, A. ; Männel, Daniela N. ; Northoff, H.

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Date of publication of this fulltext: 20 Jun 2011 06:23

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Abstract

Toxicity of lipopolysaccharide (LPS) (endotoxin) is, to a large extent, mediated by the activation of monocytes/macrophages and subsequent release of monokines, such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha). It is known that LPS binds readily to serum lipoproteins and that LPS-lipoprotein complexes are less toxic than unbound LPS. Here we present data analyzing the ...