Tumor necrosis factor mediates endotoxic effects in mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-211852
DOI to cite this document:: 10.5283/epub.21185

Bauss, F. ; Dröge, W. ; Männel, Daniela N.

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Date of publication of this fulltext: 22 Jun 2011 08:11

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Abstract

Endotoxic reactions induced in mice by recombinant human tumor necrosis factor (TNF) were examined. Mice showed a dose-dependent hypothermia after intravenous TNF injection which was similar to a reaction to lipopolysaccharide injection. Plasma glucose levels were decreased, and plasma lactate levels were increased. Blood hematocrit levels were increased after TNF injection. No interleukin-1 ...