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Tumor necrosis factor mediates endotoxic effects in mice

URN to cite this document:
urn:nbn:de:bvb:355-epub-211852
Bauss, F. ; Dröge, W. ; Männel, Daniela N.
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Date of publication of this fulltext: 22 Jun 2011 08:11


Abstract

Endotoxic reactions induced in mice by recombinant human tumor necrosis factor (TNF) were examined. Mice showed a dose-dependent hypothermia after intravenous TNF injection which was similar to a reaction to lipopolysaccharide injection. Plasma glucose levels were decreased, and plasma lactate levels were increased. Blood hematocrit levels were increased after TNF injection. No interleukin-1 ...

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