Biological aspects of tumor necrosis factor

URN to cite this document:: urn:nbn:de:bvb:355-epub-211900
DOI to cite this document:: 10.5283/epub.21190

Männel, Daniela N.

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Date of publication of this fulltext: 22 Jun 2011 09:24

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Abstract

Tumor necrosis factor (TNF) has been determined as an endogenous mediator for endotoxin-induced tumor necrosis. This macrophage product has been biochemically characterized and its protein structure defined by molecular cloning of the TNF gene. Experiments with antibodies to TNF demonstrated that TNF acts as an effector molecule of activated cytotoxic macrophages involved in tumor destruction. ...