Mechanism of lipopolysaccharide-induced tumor necrosis: requirement for lipopolysaccharide-sensitive lymphoreticular cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-212091
DOI to cite this document:: 10.5283/epub.21209

Männel, D. N. ; Rosenstreich, D. L. ; Mergenhagen, S. E.

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Date of publication of this fulltext: 22 Jun 2011 08:07

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Abstract

Lipopolysaccharide (LPS) induces rapid necrosis of intradermal fibrosarcomas in mice. The mechanism(s) by which LPS produces tumor necrosis has been investigated using histocompatible LPS-sensitive (C3H/HeN) and LPS-resistant (C3H/HeJ) mouse strains. C3H/HeN- or C3H/HeJ-derived fibrosarcomas were necrotized by LPS when they were grafted onto C3H/HeN mice but were not affected when growing on ...