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Mechanism of lipopolysaccharide-induced tumor necrosis: requirement for lipopolysaccharide-sensitive lymphoreticular cells

Männel, D.N., Rosenstreich, D. L. and Mergenhagen, S. E. (1979) Mechanism of lipopolysaccharide-induced tumor necrosis: requirement for lipopolysaccharide-sensitive lymphoreticular cells. Infection and immunity 24 (2), pp. 573-576.

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Abstract

Lipopolysaccharide (LPS) induces rapid necrosis of intradermal fibrosarcomas in mice. The mechanism(s) by which LPS produces tumor necrosis has been investigated using histocompatible LPS-sensitive (C3H/HeN) and LPS-resistant (C3H/HeJ) mouse strains. C3H/HeN- or C3H/HeJ-derived fibrosarcomas were necrotized by LPS when they were grafted onto C3H/HeN mice but were not affected when growing on ...

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Item type:Article
Date:1979
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
457286PubMed ID
Classification:
NotationType
AnimalsMESH
Endotoxins/pharmacologyMESH
Fibrosarcoma/pathologyMESH
Lipopolysaccharides/pharmacologyMESH
Lymphocytes/drug effectsMESH
MiceMESH
Mononuclear Phagocyte System/drug effectsMESH
NecrosisMESH
Neoplasms, Experimental/pathologyMESH
Skin Neoplasms/pathologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:21209
Owner only: item control page

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