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Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer

Wirtenberger, Michael, Tchatchou, Sandrine, Hemminki, Kari, Schmutzhard, Julia, Sutter, Christian, Schmutzler, Rita K., Meindl, Alfons, Wappenschmidt, Barbara, Kiechle, Marion, Arnold, Norbert, Weber, Bernhard H. F., Niederacher, Dieter, Bartram, Claus R. and Burwinkel, Barbara (2006) Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer. Carcinogenesis 27 (11), pp. 2201-2208.

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Date of publication of this fulltext: 05 Aug 2009 13:36

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Other URL: http://dx.doi.org/10.1093/carcin/bgl067, http://carcin.oxfordjournals.org/cgi/content/abstract/27/11/2201


Abstract

The mitogen effect of the ovarian steroid estrogen is a strong risk factor for breast cancer development. This effect is mainly mediated by the estrogen receptor alpha, a hormone inducible transcription factor, which activates gene expression through recruiting multiple coactivators, such as PPARGC1A, PPARGC1B and EP300. We tested the hypothesis that non-conservative, putative functional amino ...

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Item type:Article
Date:November 2006
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
16704985PubMed ID
10.1093/carcin/bgl067DOI
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:2127
Owner only: item control page

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