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Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer

DOI to cite this document:
10.5283/epub.2127
Wirtenberger, Michael ; Tchatchou, Sandrine ; Hemminki, Kari ; Schmutzhard, Julia ; Sutter, Christian ; Schmutzler, Rita K. ; Meindl, Alfons ; Wappenschmidt, Barbara ; Kiechle, Marion ; Arnold, Norbert ; Weber, Bernhard H. F. ; Niederacher, Dieter ; Bartram, Claus R. ; Burwinkel, Barbara
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Date of publication of this fulltext: 05 Aug 2009 13:36


Abstract

The mitogen effect of the ovarian steroid estrogen is a strong risk factor for breast cancer development. This effect is mainly mediated by the estrogen receptor alpha, a hormone inducible transcription factor, which activates gene expression through recruiting multiple coactivators, such as PPARGC1A, PPARGC1B and EP300. We tested the hypothesis that non-conservative, putative functional amino ...

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