Go to content
UR Home

Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer

DOI to cite this document:
10.5283/epub.2128
Wirtenberger, Michael ; Frank, Bernd ; Hemminki, Kari ; Klaes, Rüdiger ; Schmutzler, Rita K. ; Wappenschmidt, Barbara ; Meindl, Alfons ; Kiechle, Marion ; Arnold, Norbert ; Weber, Bernhard H. F. ; Niederacher, Dieter ; Bartram, Claus R. ; Burwinkel, Barbara
[img]PDF
(98kB) - Repository staff only
Date of publication of this fulltext: 05 Aug 2009 13:36


Abstract

Mutations of the human RecQ helicase genes WRN and BLM lead to rare autosomal recessive disorders, Werner and Bloom syndromes, which are associated with premature ageing and cancer predisposition. We tested the hypothesis whether three polymorphic, non-conservative amino acid exchanges in WRN and BLM act as low-penetrance familial breast cancer risk factors. Moreover, we examined the putative ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons