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Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer

Wirtenberger, Michael, Frank, Bernd, Hemminki, Kari, Klaes, Rüdiger, Schmutzler, Rita K., Wappenschmidt, Barbara, Meindl, Alfons, Kiechle, Marion, Arnold, Norbert, Weber, Bernhard H. F., Niederacher, Dieter, Bartram, Claus R. and Burwinkel, Barbara (2006) Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer. Carcinogenesis 27 (8), pp. 1655-1660.

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Date of publication of this fulltext: 05 Aug 2009 13:36

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Other URL: http://dx.doi.org/10.1093/carcin/bgi374, http://carcin.oxfordjournals.org/cgi/content/abstract/27/8/1655


Abstract

Mutations of the human RecQ helicase genes WRN and BLM lead to rare autosomal recessive disorders, Werner and Bloom syndromes, which are associated with premature ageing and cancer predisposition. We tested the hypothesis whether three polymorphic, non-conservative amino acid exchanges in WRN and BLM act as low-penetrance familial breast cancer risk factors. Moreover, we examined the putative ...

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Item type:Article
Date:August 2006
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1093/carcin/bgi374DOI
16501249PubMed ID
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:2128
Owner only: item control page

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