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Abstract
We describe the synthesis of spherical poly(vinyl butyral) (PVB) nanobeads by controlled pptn. via addn. of non-solvent. Effects of various reaction parameters on nanoparticle size were investigated by dynamic light scattering and electron microscopy. The ability to incorporate dopant mols. was studied using a fluorescent perylene deriv. as a model additive, and the dye-doped nanoparticles were ...
Abstract
We describe the synthesis of spherical poly(vinyl butyral) (PVB) nanobeads by controlled pptn. via addn. of non-solvent. Effects of various reaction parameters on nanoparticle size were investigated by dynamic light scattering and electron microscopy. The ability to incorporate dopant mols. was studied using a fluorescent perylene deriv. as a model additive, and the dye-doped nanoparticles were investigated by confocal microscopy. In an optimized exptl. protocol, PVB nanoparticles were obtained that were efficiently taken up by human cancer cells devoid of coating. The novel nanospheres are economic, easy to prep. and capable of incorporating additives. Lacking cytotoxicity in vitro, PVB nanobeads are attractive with respect to various potential applications such as optical imaging and particle tracking, diagnostics, and drug delivery. [on SciFinder(R)]
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