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Are hypotension and rash after atracurium really caused by histamine release?

URN to cite this document:
Doenicke, A. ; Moss, J. ; Lorenz, Wilfried ; Hoernecke, R. ; Gottardis, M.
Date of publication of this fulltext: 12 Aug 2011 05:51


A prospective, randomized, double-blind study was performed in 40 patients (ASA class I-III) treated with atracurium to ascertain whether histamine release caused hemodynamic or cutaneous changes. The treated group of 20 patients was premedicated with the H1 antagonist dimetindene (0.2 mg/kg) and the H2 antagonist ranitidine (1.25 mg/kg); the control group of 20 patients received saline. Six ...


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