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Incidence and clinical importance of perioperative histamine release: randomised study of volume loading and antihistamines after induction of anaesthesia

URN to cite this document:
urn:nbn:de:bvb:355-epub-217521
Lorenz, Wilfried ; Duda, D. ; Dick, W. ; Sitter, H. ; Doenicke, A. ; Black, A. ; Weber, Doris ; Menke, H. ; Stinner, B. ; Junginger, T. ; Trial Group, Mainz/Marburg
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Date of publication of this fulltext: 16 Aug 2011 12:01


Abstract

Although histamine release is recognised as a common event during anaesthesia and surgery, few clinicians judge the resultant cardiorespiratory disturbances serious enough to warrant prophylaxis with antihistamines. We have assessed the incidence and importance of histamine release in a randomised 2 x 2 factorial study. 240 patients representing a routine throughput of major general surgery were ...

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