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Sample taking problems in measuring actual histamine levels of human gastroduodenal mucosa: specific and general relevance in clinical trials on peptic ulcer pathogenesis and selective proximal vagotomy

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Thon, K. P. ; Lorenz, Wilfried ; Ohmann, C. ; Weber, D. ; Rohde, H. ; Röher, H. D.
Date of publication of this fulltext: 18 Aug 2011 13:01


Changes in histamine storage in the oxyntic mucosa of duodenal ulcer patients and their reversal by vagotomy and the histamine H2-antagonist cimetidine supported the hypothesis that histamine could be a causal factor in peptic ulcer pathogenesis. The specificity of these findings was impaired by problems in biopsy taking, however, and in the preparative steps before measuring the actual histamine ...


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