Modulation of histamine release by fatty acids. A new in vitro model investigating adverse drug reactions in various species

URN to cite this document:

urn:nbn:de:bvb:355-epub-218039 Copy

DOI to cite this document:

10.5283/epub.21803 Copy

Ennis, M. ; Lorenz, Wilfried

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Date of publication of this fulltext: 19 Aug 2011 11:27

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Details

Item type:	Article
Journal or Publication Title:	Annales françaises d'anesthèsie et de rèanimation
Publisher:	Masson (Paris); Elsevier
Volume:	4
Number of Issue or Book Chapter:	2
Page Range:	pp. 124-128
Date:	1985
Institutions:	Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V.
Identification Number:	Value Type 2408508 PubMed ID 10.1016/S0750-7658(85)80185-4 DOI
Classification:	Notation Type Alfaxalone Alfadolone Mixture/toxicity MESH Anesthetics/toxicity MESH Animals MESH Dogs MESH Fatty Acids/pharmacology MESH Female MESH Glycerol/toxicity MESH Guinea Pigs MESH Histamine/blood MESH Histamine Release/drug effects MESH Humans MESH Male MESH Mast Cells/secretion MESH Propanidid/toxicity MESH Rats MESH
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	21803

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Abstract

Histamine release caused by drugs and/or their solvents is a well known phenomenon. In this study, both in vivo (anaesthetized and conscious dogs) and in vitro (isolated rat peritoneal, human and guinea-pig lung mast cells) models were used. Cremophor E1 and six derivatives of 12-hydroxystearic acid were compared for their histamine releasing abilities. Although the three types of isolated mast ...

Abstract

Histamine release caused by drugs and/or their solvents is a well known phenomenon. In this study, both in vivo (anaesthetized and conscious dogs) and in vitro (isolated rat peritoneal, human and guinea-pig lung mast cells) models were used. Cremophor E1 and six derivatives of 12-hydroxystearic acid were compared for their histamine releasing abilities. Although the three types of isolated mast cells responded similarly, histamine release being observed with DH (the diester of 12-hydroxystearic acid with polyethylene glycol), TN (12-hydroxystearic acid polymerized with ethylene oxide) and ME (the monoester of 12-hydroxystearic acid esterified with polyethylene glycol), the anaesthetized dog exhibited elevated blood histamine levels and clinical symptoms after administration of all the solubilizing agents, except TN and ME. The reasons for this discrepancy are not known. The addition of the drugs (Althesin or propanidid) to their solubilizing agents caused histamine release, which was not observed with the solubilizing agent alone. This is the first demonstration of an in vitro model, which copies the clinical situation, i.e. solvent does nothing but the solvent plus drug combination causes histamine release and hence adverse reactions.

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