Modulation of histamine release by fatty acids. A new in vitro model investigating adverse drug reactions in various species

URN to cite this document:: urn:nbn:de:bvb:355-epub-218039
DOI to cite this document:: 10.5283/epub.21803

Ennis, M. ; Lorenz, Wilfried

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Date of publication of this fulltext: 19 Aug 2011 11:27

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Abstract

Histamine release caused by drugs and/or their solvents is a well known phenomenon. In this study, both in vivo (anaesthetized and conscious dogs) and in vitro (isolated rat peritoneal, human and guinea-pig lung mast cells) models were used. Cremophor E1 and six derivatives of 12-hydroxystearic acid were compared for their histamine releasing abilities. Although the three types of isolated mast ...