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Effects of propofol ('Diprivan') on histamine release, immunoglobulin levels and activation of complement in healthy volunteers

Doenicke, A. ; Lorenz, Wilfried ; Stanworth, D. ; Duka, T. ; Glen, J. B.


This randomized study compared the effects of the emulsion formulation of propofol with those of the Cremophor-containing agent Althesin. Plasma histamine concentration, immunoglobulin levels, total complement C3 and complement C3 conversion were measured prior to and following induction of anaesthesia in 32 male volunteers with either 2 mg/kg propofol or 0.05 ml/kg Althesin. In only one ...


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