Prophylaxis of anaphylactoid reactions to a polypeptidal plasma substitute by H1- plus H2-receptor antagonists: synopsis of three randomized controlled trials

URN to cite this document:: urn:nbn:de:bvb:355-epub-218602
DOI to cite this document:: 10.5283/epub.21860

Schöning, B. ; Lorenz, Wilfried ; Doenicke, A.

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Date of publication of this fulltext: 22 Aug 2011 14:09

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Abstract

To demonstrate the efficacy of a premedication with H1- + H2-receptor antagonists against histamine-release responses in anaesthesia and surgery 3 randomized controlled trials were conducted in patients, volunteers and experimental animals (dogs). Cutaneous anaphylactoid reactions following infusion of polygeline (Haemaccel) in orthopedic patients were successfully abolished by premedication with ...