Histamine and peptic ulcer: a prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases

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urn:nbn:de:bvb:355-epub-218701 Copy

Troidl, H. ; Lorenz, Wilfried ; Rohde, H. ; Häfner, G. ; Ronzheimer, M.

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Date of publication of this fulltext: 23 Aug 2011 07:18

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Details

Item type:	Article
Journal or Publication Title:	Klinische Wochenschrift
Publisher:	Springer
Volume:	54
Number of Issue or Book Chapter:	19
Page Range:	pp. 947-956
Date:	1976
Institutions:	Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V.
Identification Number:	Value Type 979074 PubMed ID
Classification:	Notation Type Duodenal Ulcer/metabolism MESH Gastric Mucosa/analysis MESH Gastrointestinal Diseases/metabolism MESH Histamine/analysis MESH Humans MESH Male MESH Prospective Studies MESH
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	21870

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Abstract

In a prospective study the histamine content of the mucosa of the body of the stomach was measured in 100 patients consisting of control subjects, patients with duodenal ulcer and patients suffering from various gastrointestinal diseases. The histamine content was found to be 43 mug/g in male control subjects (median) while in duodenal ulcer patients levels attained were significantly lower by ...

Abstract

In a prospective study the histamine content of the mucosa of the body of the stomach was measured in 100 patients consisting of control subjects, patients with duodenal ulcer and patients suffering from various gastrointestinal diseases. The histamine content was found to be 43 mug/g in male control subjects (median) while in duodenal ulcer patients levels attained were significantly lower by about 30 per cent. In all the other groups of patients histamine concentrations in gastric mucosa were found to be "normal". Since in most species it is extremely diffcult to alter the mucosal histamine concentration by any form of treatment, the diminished histamine content of the gastric mucosa in patients with duodenal ulcer seems remarkable. Among several possible explanations offered for this finding we think the most likely is that histamine release is increased in duodenal ulcer disease.

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