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Histamine release in human subjects by modified gelatin (Haemaccel) and dextran: an explanation for anaphylactoid reactions observed under clinical conditions?

Lorenz, Wilfried, Doenicke, A., Messmer, K., Reimann, H. J., Thermann, M., Lahn, W., Berr, J., Schmal, A., Dormann, P., Regenfuss, P. and Hamelmann, H. (1976) Histamine release in human subjects by modified gelatin (Haemaccel) and dextran: an explanation for anaphylactoid reactions observed under clinical conditions? British journal of anaesthesia 48 (2), pp. 151-165.

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Abstract

Histamine release by modified gelatin (Haemaccel) and dextran (Macrodex) has been demonstrated in volunteers by direct and indirect methods. In a pilot study of Haemaccel, histamine release was observed in six of seven volunteers. The highest plasma histamine concentration was 4.8 ng/ml, the lowest 1.7 ng/ml: two of the subjects showed slight allergic reactions. Using Haemaccel batch 2551, 10 out ...

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Item type:Article
Date:1976
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V.
Identification Number:
ValueType
56183PubMed ID
Classification:
NotationType
AdultMESH
Anaphylaxis/chemically inducedMESH
BasophilsMESH
Blood Pressure/drug effectsMESH
Dextrans/toxicityMESH
Drug HypersensitivityMESH
FemaleMESH
Gastric Juice/drug effectsMESH
GranulocytesMESH
Heart Rate/drug effectsMESH
Histamine/bloodMESH
Histamine Release/drug effectsMESH
HumansMESH
Leukocyte CountMESH
MaleMESH
Polygeline/toxicityMESH
Polymers/toxicityMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:21877
Owner only: item control page

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