Histamine release in human subjects by modified gelatin (Haemaccel) and dextran: an explanation for anaphylactoid reactions observed under clinical conditions?

URN to cite this document:: urn:nbn:de:bvb:355-epub-218772
DOI to cite this document:: 10.5283/epub.21877

Lorenz, Wilfried ; Doenicke, A. ; Messmer, K. ; Reimann, H. J. ; Thermann, M. ; Lahn, W. ; Berr, J. ; Schmal, A. ; Dormann, P. ; Regenfuss, P. ; Hamelmann, H.

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Date of publication of this fulltext: 23 Aug 2011 06:31

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Abstract

Histamine release by modified gelatin (Haemaccel) and dextran (Macrodex) has been demonstrated in volunteers by direct and indirect methods. In a pilot study of Haemaccel, histamine release was observed in six of seven volunteers. The highest plasma histamine concentration was 4.8 ng/ml, the lowest 1.7 ng/ml: two of the subjects showed slight allergic reactions. Using Haemaccel batch 2551, 10 out ...