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Effect of amodiaquine on gastric histamine methyltransferase and on histamine-stimulated gastric secretion

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Barth, H. ; Lorenz, Wilfried ; Troidl, H.
Date of publication of this fulltext: 23 Aug 2011 06:32


1 Amodiaquine was found to be a potent inhibitor in vitro of gastric histamine methyltransferase from human and canine corpus and from pig antrum. The ID50 for the enzyme, purified from pig antrum mucosa by ultracentrifugation and chromatography on DEAE-cellulose, was 2.5 muM. 2 In six dogs with Heidenhanin pouches the maximum secretory response to histamine (40 mug/kg i.m.) was augmented by i.m. ...


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