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Histamine liberation in man following plasma substitution with gelatine and dextran: cause of anaphylactic reactions in the hospital? (transl.)

Thermann, M. ; Doenicke, A. ; Messmer, K. ; Hamelmann, H. ; Reimann, J. ; Lorenz, Wilfried


After rapid gelatin infusion in many cases a release of relatively small amounts of histamine was observed. Clinical symptoms occured in 5 cases in correspondence to the increased histamine levels, but were relatively harmless. The application of dextran 60 induced anaphylactoid reactions in 2 persons, with death in one case. Plasma histamine level were normal in both cases. Histamine release probably is not the cause of dextrn induced anaphylactoid reactions.

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