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An improved method for the determination of histamine release in man: its application in studies with propanidid and thiopentone

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Lorenz, Wilfried ; Doenicke, A. ; Meyer, R. ; Reimann, H. J. ; Kusche, J. ; Barth, H. ; Geesing, H. ; Hutzel, M. ; Weissenbacher, B.
Date of publication of this fulltext: 25 Aug 2011 08:12


Histamine release by propanidid and thiopentone was demonstrated with the use of a highly sensitive and specific method for determining histamine in human plasma. 5 min after i.v. administration of propanidid and 3 min after thiopentone, the plasma histamine level was increased by 350 and 420% respectively. In whole blood, histamine release could be demonstrated only when the basophil content ...


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