Control of renin gene expression in 2 kidney-1 clip rats

URN to cite this document:: urn:nbn:de:bvb:355-epub-220376

Schricker, K. ; Holmer, S. ; Krämer, Bernhard K. ; Riegger, G. ; Kurtz, Armin

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Date of publication of this fulltext: 08 Sep 2011 06:40

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Abstract

This study was done to investigate the mechanisms that underly the changes of renal renin gene expression upon hypoperfusion of one kidney. To this end the left renal arteries of male Sprague-Dawley rats were clipped with 0.2 mm silver clips and renal renin mRNA levels were assayed by RNase protection during the first ten days after clipping. Unilateral reduction of renal blood flow led to ...