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Hemodynamic and inotropic effects of endothelin-1 in vivo

Beyer, M. E., Nerz, S., Krämer, Bernhard K. and Hoffmeister, H. M. (1994) Hemodynamic and inotropic effects of endothelin-1 in vivo. Basic research in cardiology 89 (1), pp. 39-49.

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Abstract

Endothelin-1 (ET-1) is known to have strong vasoactive properties. Contradictory results have been reported with regard to its inotropic effects. This study examined the dose-dependent (500, 1000, 2500, 5000 and 10,000 ng ET-1/kg vs. NaCl controls) hemodynamic and inotropic effects of ET-1 in 53 open-chest rats during and after a 7-min infusion. Besides measurements in the intact circulation the ...

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Item type:Article
Date:1994
Institutions:UNSPECIFIED
Identification Number:
ValueType
8010934PubMed ID
Classification:
NotationType
AnimalsMESH
Blood Pressure/drug effectsMESH
Cardiac Output/drug effectsMESH
Dose-Response Relationship, DrugMESH
Electrocardiography/drug effectsMESH
Endothelins/pharmacologyMESH
Heart/physiologyMESH
Heart Rate/drug effectsMESH
Hemodynamics/drug effectsMESH
Infusions, IntravenousMESH
MaleMESH
Myocardial Contraction/drug effectsMESH
RatsMESH
Rats, WistarMESH
Reference ValuesMESH
Systole/drug effectsMESH
Time FactorsMESH
Vascular Resistance/drug effectsMESH
Ventricular Function, Left/physiologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:22041
Owner only: item control page

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