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Hemodynamic and inotropic effects of endothelin-1 in vivo

URN to cite this document:
Beyer, M. E. ; Nerz, S. ; Krämer, Bernhard K. ; Hoffmeister, H. M.
Date of publication of this fulltext: 08 Sep 2011 06:32


Endothelin-1 (ET-1) is known to have strong vasoactive properties. Contradictory results have been reported with regard to its inotropic effects. This study examined the dose-dependent (500, 1000, 2500, 5000 and 10,000 ng ET-1/kg vs. NaCl controls) hemodynamic and inotropic effects of ET-1 in 53 open-chest rats during and after a 7-min infusion. Besides measurements in the intact circulation the ...


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