Effect of endothelium-derived relaxing factor on renin secretion from isolated mouse renal juxtaglomerular cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-220434
DOI to cite this document:: 10.5283/epub.22043

Schricker, K. ; Ritthaler, T. ; Krämer, Bernhard K. ; Kurtz, Armin

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Date of publication of this fulltext: 08 Sep 2011 06:15

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Abstract

This study aimed to examine the direct influence of native endothelium derived relaxing factor (EDRF) on renin secretion. To this end isolated mouse renal juxtaglomerular cells were cocultured with bovine aortic endothelial cells which produced and released significant amounts of EDRF as assayed by guanylate cyclase activities which were measured separately in endothelial and juxtaglomerular ...