Krämer, Bernhard K., Nishida, M., Kelly, R. A. and Smith, T. W.
(1992)
Endothelins. Myocardial actions of a new class of cytokines.
Circulation 85 (1), pp. 350-356.
Date of publication of this fulltext: 09 Sep 2011 09:00at PubMed
Abstract
There is growing evidence to support the existence of a dynamic interaction in vivo between cardiac myocytes and adjacent microvascular endothelial cells in the regulation of both cardiac myocyte and possibly endothelial cell phenotype and function. Endothelins may be only one of several endogenous cytokines or autocoids that are released by the cardiac microvascular and/or endocardial ...
Abstract
There is growing evidence to support the existence of a dynamic interaction in vivo between cardiac myocytes and adjacent microvascular endothelial cells in the regulation of both cardiac myocyte and possibly endothelial cell phenotype and function. Endothelins may be only one of several endogenous cytokines or autocoids that are released by the cardiac microvascular and/or endocardial endothelium and transported vectorially to adjacent myocytes that could modify cardiac contractile state, perhaps in response to changes in microvascular blood flow. Similarly, cardiac myocytes themselves could release cytokines that could directly affect endothelial cell proliferation or angiogenesis and indirectly elicit or modify the release of endothelium-derived cytokines and autocoids. Thus, in addition to modifying function, endothelial cell-cardiac myocyte interactions may also be of importance in the dynamic events that lead to myocardial wall remodeling and angiogenesis during hypertrophic growth and in the response to cardiac injury.
Export bibliographical data
| Item type: | Article |
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| Date: | 1992 |
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| Institutions: | UNSPECIFIED |
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| Identification Number: | | Value | Type |
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| 1728467 | PubMed ID |
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| Classification: | | Notation | Type |
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| Amino Acid Sequence | MESH | | Animals | MESH | | Coronary Circulation | MESH | | Cytokines/pharmacology | MESH | | Endothelins/pharmacology | MESH | | Endothelium, Vascular/physiology | MESH | | Heart/physiology | MESH | | Humans | MESH | | Molecular Sequence Data | MESH | | Myocardial Contraction/drug effects | MESH | | Myocardium/cytology | MESH |
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| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine |
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| Status: | Published |
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| Refereed: | Yes, this version has been refereed |
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| Created at the University of Regensburg: | Unknown |
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| Item ID: | 22050 |
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