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Pharmacokinetic and blood pressure effects of carvedilol in patients with chronic renal failure

URN to cite this document:
Krämer, Bernhard K. ; Ress, K. M. ; Erley, C. M. ; Risler, T.
Date of publication of this fulltext: 08 Sep 2011 06:29


The pharmacokinetic and acute systemic haemodynamic effects of a single oral dose of 50 mg carvedilol has been studied in 24 hypertensive patients with chronic renal failure. The patients were stratified into 3 groups according to the creatinine clearance: I 51-90 ml.min-1; II 26-50 ml.min-1; III 4-25 ml.min-1. The area under plasma level time curve AUC, the elimination half-life t1/2, the ...


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