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Simplified, rapid and inexpensive extraction procedure for a high-performance liquid chromatographic method for determination of disopyramide and its main metabolite mono-N-dealkylated disopyramide in serum

URN to cite this document:
urn:nbn:de:bvb:355-epub-220536
Mayer, F. ; Krämer, Bernhard K. ; Ress, K. M. ; Kühlkamp, V. ; Liebich, H. M. ; Risler, T. ; Seipel, L.
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Date of publication of this fulltext: 09 Sep 2011 14:35


Abstract

A simplified, rapid and inexpensive extraction procedure for the determination of the antiarrhythmic drug disopyramide and its main metabolite mono-N-desalkylated disopyramide in serum by high-performance liquid chromatography has been developed. The analysis uses ultraviolet detection at 254 nm, and a 5 micron reversed-phase column with a mobile phase of water-triethylamine-acetonitrile-PIC-B8 ...

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