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Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger

Krämer, Bernhard K., Smith, T. W. and Kelly, R. A. (1991) Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger. Circulation research 68 (1), pp. 269-279.

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Date of publication of this fulltext: 09 Sep 2011 14:39

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Abstract

Endothelin, a 21-amino acid vasoactive peptide, is among the most potent positively inotropic agents yet described in mammalian heart. Having demonstrated that endothelin's inotropic effect is due, in part, to an apparent sensitization of cardiac myofilaments to intracellular calcium, we determined whether this could be due to a rise in intracellular pH (pHi). In isolated adult rat ventricular ...

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Item type:Article
Date:1991
Institutions:UNSPECIFIED
Identification Number:
ValueType
1845855PubMed ID
Classification:
NotationType
Alkalosis/metabolismMESH
Ammonium Chloride/pharmacologyMESH
AnimalsMESH
Carrier Proteins/metabolismMESH
Endothelins/physiologyMESH
Heart VentriclesMESH
Hydrogen-Ion ConcentrationMESH
Intracellular Membranes/metabolismMESH
Myocardial ContractionMESH
Myocardium/cytologyMESH
Ouabain/pharmacologyMESH
Protein Kinase C/pharmacologyMESH
RatsMESH
Sodium-Hydrogen AntiporterMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:22055
Owner only: item control page

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