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Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway

Kelly, R. A., Eid, H., Krämer, Bernhard K., O'Neill, M., Liang, B. T., Reers, M. and Smith, T. W. (1990) Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway. The Journal of clinical investigation 86 (4), pp. 1164-1171.

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Abstract

It has long been assumed that the primary influences regulating cardiac contractility are the extent of mechanical loading of muscle fibers and the activity of the autonomic nervous system. However, the vasoactive peptide endothelin, initially found in vascular endothelium, is among the most potent positively inotropic agents yet described in mammalian myocardium. In isolated adult rat ...

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Item type:Article
Date:1990
Additional Information (public):Erratum in: J Clin Invest 1991 Apr;87(4):following 1477
Institutions:UNSPECIFIED
Identification Number:
ValueType
2120283PubMed ID
10.1172/JCI114822DOI
Classification:
NotationType
AnimalsMESH
Calcium/physiologyMESH
Endothelins/pharmacologyMESH
Endothelium/physiologyMESH
GTP-Binding Proteins/physiologyMESH
Isoproterenol/pharmacologyMESH
Myocardial Contraction/drug effectsMESH
Pertussis ToxinMESH
RatsMESH
Verapamil/pharmacologyMESH
Virulence Factors, Bordetella/pharmacologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:22057
Owner only: item control page

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