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Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway

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Kelly, R. A. ; Eid, H. ; Krämer, Bernhard K. ; O'Neill, M. ; Liang, B. T. ; Reers, M. ; Smith, T. W.
Date of publication of this fulltext: 09 Sep 2011 14:42


It has long been assumed that the primary influences regulating cardiac contractility are the extent of mechanical loading of muscle fibers and the activity of the autonomic nervous system. However, the vasoactive peptide endothelin, initially found in vascular endothelium, is among the most potent positively inotropic agents yet described in mammalian myocardium. In isolated adult rat ...


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