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Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium

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Chambers, Karen F. ; Pearson, Joanna F. ; Pellacani, Davide ; Aziz, Naveed ; Gužvić, Miodrag ; Klein, Christoph A. ; Lang, Shona H.
Date of publication of this fulltext: 26 Sep 2011 09:36


In 3D prostate cultures, stromal cells increase lateral epithelial cell adhesions. We show that this morphological effect is associated with gene expression changes to TGF beta signalling, cytoskeleton and anion activity.

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