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Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition

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Hackl, Christina ; Lang, Sven A. ; Moser, Christian ; Mori, Akira ; Fichtner-Feigl, Stefan ; Hellerbrand, Claus ; Dietmeier, Wolfgang ; Schlitt, Hans J. ; Geissler, Edward K. ; Stoeltzing, Oliver
Date of publication of this fulltext: 26 Sep 2011 09:44


In conclusion, ATF3 down-regulation in colon cancer promotes tumor growth and metastasis. Considering that blocking Hsp90 induces ATF3 expression, Hsp90 inhibition may represent a valid strategy to treat metastatic colon cancer by up-regulating this anti-metastatic transcription factor.

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