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Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation

He, Shuying, Pirity, Melinda K., Wang, Wei-Lin, Wolf, Louise, Chauhan, Bharesh K., Cveklova, Kveta, Tamm, Ernst R., Ashery-Padan, Ruth, Metzger, Daniel, Nakai, Akira, Chambon, Pierre, Zavadil, Jiri and Cvekl, Ales (2010) Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics & chromatin 3 (1), p. 21.

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Date of publication of this fulltext: 26 Sep 2011 09:46

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Abstract

These studies demonstrate a cell-autonomous role for Brg1 in lens fiber cell terminal differentiation and identified DNase IIβ as a potential direct target of SWI/SNF complexes. Brg1 is directly or indirectly involved in processes that degrade lens fiber cell chromatin. The presence of nuclei and other organelles generates scattered light incompatible with the optical requirements for the lens.


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Item type:Article
Date:2010
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
21118511PubMed ID
10.1186/1756-8935-3-21DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:22189
Owner only: item control page

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