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Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation

URN to cite this document:
He, Shuying ; Pirity, Melinda K. ; Wang, Wei-Lin ; Wolf, Louise ; Chauhan, Bharesh K. ; Cveklova, Kveta ; Tamm, Ernst R. ; Ashery-Padan, Ruth ; Metzger, Daniel ; Nakai, Akira ; Chambon, Pierre ; Zavadil, Jiri ; Cvekl, Ales
Date of publication of this fulltext: 26 Sep 2011 09:46


These studies demonstrate a cell-autonomous role for Brg1 in lens fiber cell terminal differentiation and identified DNase IIβ as a potential direct target of SWI/SNF complexes. Brg1 is directly or indirectly involved in processes that degrade lens fiber cell chromatin. The presence of nuclei and other organelles generates scattered light incompatible with the optical requirements for the lens.

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