Comparative expression pattern of Matrix-Metalloproteinases in human glioblastoma cell-lines and primary cultures

Zusammenfassung

Literature-data and our own results suggest that the expression pattern of MMPs is highly variable, dependent on the cell-line and the cell-culture conditions used and that also regulation of MMP expression by cytokines is cell-line dependent. This is of high impact for the transfer of cell-culture experiments to clinical implementation.