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Comparative expression pattern of Matrix-Metalloproteinases in human glioblastoma cell-lines and primary cultures

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Hagemann, Carsten ; Anacker, Jelena ; Haas, Stefanie ; Riesner, Daniela ; Schömig, Beate ; Ernestus, Ralf-Ingo ; Vince, Giles H.
Date of publication of this fulltext: 26 Sep 2011 09:50


Literature-data and our own results suggest that the expression pattern of MMPs is highly variable, dependent on the cell-line and the cell-culture conditions used and that also regulation of MMP expression by cytokines is cell-line dependent. This is of high impact for the transfer of cell-culture experiments to clinical implementation.

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