The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro

URN to cite this document:: urn:nbn:de:bvb:355-epub-224215
DOI to cite this document:: 10.5283/epub.22421

Lechler, Philipp ; Balakrishnan, Sanjeevi ; Schaumburger, Jens ; Grässel, Susanne ; Baier, Clemens ; Grifka, Joachim ; Straub, Rainer H. ; Renkawitz, Tobias

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Date of publication of this fulltext: 19 Oct 2011 13:35

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Abstract

Background Regulation of cell death and cell division are key processes during chondrogenesis and in cartilage homeostasis and pathology. The oncogene survivin is considered to be critical for the coordination of mitosis and maintenance of cell viability during embryonic development and in cancer, and is not detectable in most adult differentiated tissues and cells. We analyzed survivin ...