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The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro

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Lechler, Philipp ; Balakrishnan, Sanjeevi ; Schaumburger, Jens ; Grässel, Susanne ; Baier, Clemens ; Grifka, Joachim ; Straub, Rainer H. ; Renkawitz, Tobias
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 19 Oct 2011 13:35


Background Regulation of cell death and cell division are key processes during chondrogenesis and in cartilage homeostasis and pathology. The oncogene survivin is considered to be critical for the coordination of mitosis and maintenance of cell viability during embryonic development and in cancer, and is not detectable in most adult differentiated tissues and cells. We analyzed survivin ...


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