Müller, B. M., Rosskopf, F., Paper, D. H., Kraus, J. und Franz, Gerhard
(1991)
Polysaccharide aus Nerium oleander: Struktur und biologische Aktivität [Polysaccharides from Nerium oleander: structure and biological activity].
Die Pharmazie 46 (9), S. 657-663.
Im Publikationsserver gibt es leider keinen Volltext zu diesem Eintrag.
Zum PubMed-Eintrag dieses Artikels
Zusammenfassung
A water extraction of crushed leaves of Nerium oleander yielded 2.3% of a crude polysaccharide. The main fraction (67%) represents a pectic polysaccharide mainly composed of galacturonic acid besides rhamnose, arabinose and galactose. The polysaccharide structure was characterized by NMR, mild acid- and pectinase treatment combined with GC-MS analyses. In vivo tests for a possible antitumor ...
Zusammenfassung
A water extraction of crushed leaves of Nerium oleander yielded 2.3% of a crude polysaccharide. The main fraction (67%) represents a pectic polysaccharide mainly composed of galacturonic acid besides rhamnose, arabinose and galactose. The polysaccharide structure was characterized by NMR, mild acid- and pectinase treatment combined with GC-MS analyses. In vivo tests for a possible antitumor activity did not result in a significant action. Investigation of immunomodulating activity brought some indications for mitogenic activity and a weak macrophage-mediated cytotoxicity. Increase of phagocytosis could not be doubtlessly assigned to the polysaccharide due to the high amount of endotoxin in the homogenous fraction OLE 2.
Bibliographische Daten exportieren
| Dokumentenart: | Artikel |
|---|
| Datum: | 1991 |
|---|
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Franz |
|---|
| Identifikationsnummer: | |
|---|
| Klassifikation: | | Notation | Art |
|---|
| Animals | MESH | | Antineoplastic Agents, Phytogenic/pharmacology | MESH | | Cell Survival/drug effects | MESH | | Female | MESH | | Hydrolysis | MESH | | Immunologic Factors/pharmacology | MESH | | Limulus Test | MESH | | Lymphocytes/drug effects | MESH | | Macrophages/drug effects | MESH | | Magnetic Resonance Spectroscopy | MESH | | Male | MESH | | Methylation | MESH | | Mice | MESH | | Mice, Inbred C3H | MESH | | Mitogens/pharmacology | MESH | | Phagocytosis/drug effects | MESH | | Plant Extracts/pharmacology | MESH | | Plants, Medicinal/chemistry | MESH | | Polysaccharides/pharmacology | MESH | | Protease Inhibitors/pharmacology | MESH | | Structure-Activity Relationship | MESH | | Tumor Cells, Cultured/drug effects | MESH |
|
|---|
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
|---|
| Status: | Veröffentlicht |
|---|
| Begutachtet: | Ja, diese Version wurde begutachtet |
|---|
| An der Universität Regensburg entstanden: | Unbekannt / Keine Angabe |
|---|
| Dokumenten-ID: | 22568 |
|---|
Altmetric