Polysaccharide aus Nerium oleander: Struktur und biologische Aktivität [Polysaccharides from Nerium oleander: structure and biological activity]

Müller, B. M. ; Rosskopf, F. ; Paper, D. H. ; Kraus, J. ; Franz, Gerhard

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Details

Item type:	Article
Journal or Publication Title:	Die Pharmazie
Publisher:	Govi-Verl., Pharmazeut. Verl.
Volume:	46
Number of Issue or Book Chapter:	9
Page Range:	pp. 657-663
Date:	1991
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Franz
Identification Number:	Value Type 1798730 PubMed ID
Classification:	Notation Type Animals MESH Antineoplastic Agents, Phytogenic/pharmacology MESH Cell Survival/drug effects MESH Female MESH Hydrolysis MESH Immunologic Factors/pharmacology MESH Limulus Test MESH Lymphocytes/drug effects MESH Macrophages/drug effects MESH Magnetic Resonance Spectroscopy MESH Male MESH Methylation MESH Mice MESH Mice, Inbred C3H MESH Mitogens/pharmacology MESH Phagocytosis/drug effects MESH Plant Extracts/pharmacology MESH Plants, Medicinal/chemistry MESH Polysaccharides/pharmacology MESH Protease Inhibitors/pharmacology MESH Structure-Activity Relationship MESH Tumor Cells, Cultured/drug effects MESH
Dewey Decimal Classification:	500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	22568

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Abstract

A water extraction of crushed leaves of Nerium oleander yielded 2.3% of a crude polysaccharide. The main fraction (67%) represents a pectic polysaccharide mainly composed of galacturonic acid besides rhamnose, arabinose and galactose. The polysaccharide structure was characterized by NMR, mild acid- and pectinase treatment combined with GC-MS analyses. In vivo tests for a possible antitumor ...

Abstract

A water extraction of crushed leaves of Nerium oleander yielded 2.3% of a crude polysaccharide. The main fraction (67%) represents a pectic polysaccharide mainly composed of galacturonic acid besides rhamnose, arabinose and galactose. The polysaccharide structure was characterized by NMR, mild acid- and pectinase treatment combined with GC-MS analyses. In vivo tests for a possible antitumor activity did not result in a significant action. Investigation of immunomodulating activity brought some indications for mitogenic activity and a weak macrophage-mediated cytotoxicity. Increase of phagocytosis could not be doubtlessly assigned to the polysaccharide due to the high amount of endotoxin in the homogenous fraction OLE 2.

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