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Sulfated β-(1→4)-galacto-oligosaccharides and their effect on angiogenesis

Käsbauer, C. W. ; Paper, D. H. ; Franz, Gerhard


Sulfated β-(1→4)-galacto-oligosaccharides were prepared from an arabino-galacto-rhamno-galacturonan from Lupinus polyphyllus Lindl. by successive partial hydrolysis and SO3–pyridine sulfation in DMF. The resulting oligosaccharide polysulfates were analyzed by analytical GPC and the sulfate content was determined by ion chromatography. DP 5 and higher showed a pronounced antiangiogenic effect with ...


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