Käsbauer, C. W. ; Paper, D. H. ; Franz, Gerhard
Alternative Links zum Volltext:Pubmed
| Dokumentenart: | Artikel |
|---|
| Titel eines Journals oder einer Zeitschrift: | Carbohydrate research |
|---|
| Verlag: | Elsevier |
|---|
| Band: | 330 |
|---|
| Nummer des Zeitschriftenheftes oder des Kapitels: | 3 |
|---|
| Seitenbereich: | S. 427-430 |
|---|
| Datum: | 2001 |
|---|
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Franz |
|---|
| Identifikationsnummer: | |
|---|
| Klassifikation: | | Notation | Art |
|---|
| Allantois/blood supply | MESH | | Angiogenesis Inhibitors/pharmacology | MESH | | Animals | MESH | | Carbohydrate Conformation | MESH | | Carbohydrate Sequence | MESH | | Chick Embryo | MESH | | Chorion/blood supply | MESH | | Fabaceae/chemistry | MESH | | Molecular Sequence Data | MESH | | Neovascularization, Physiologic/drug effects | MESH | | Oligosaccharides/pharmacology | MESH | | Plants, Medicinal | MESH | | Polysaccharides/isolation & purification | MESH |
|
|---|
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
|---|
| Status: | Veröffentlicht |
|---|
| Begutachtet: | Ja, diese Version wurde begutachtet |
|---|
| An der Universität Regensburg entstanden: | Unbekannt / Keine Angabe |
|---|
| Dokumenten-ID: | 22620 |
|---|
Zusammenfassung
Sulfated β-(1→4)-galacto-oligosaccharides were prepared from an arabino-galacto-rhamno-galacturonan from Lupinus polyphyllus Lindl. by successive partial hydrolysis and SO3–pyridine sulfation in DMF. The resulting oligosaccharide polysulfates were analyzed by analytical GPC and the sulfate content was determined by ion chromatography. DP 5 and higher showed a pronounced antiangiogenic effect with ...
Zusammenfassung
Sulfated β-(1→4)-galacto-oligosaccharides were prepared from an arabino-galacto-rhamno-galacturonan from Lupinus polyphyllus Lindl. by successive partial hydrolysis and SO3–pyridine sulfation in DMF. The resulting oligosaccharide polysulfates were analyzed by analytical GPC and the sulfate content was determined by ion chromatography. DP 5 and higher showed a pronounced antiangiogenic effect with scores of 0.9–1.2 for DP 7–9 using the CAM-assay. An interaction with the fibroblast growth factor FGF-2 was noticed for DP 4–12 depending on the degree of sulfation using the FGF-2-trypsin assay.
Altmetric