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Synthesis and antitumour activity of sulfoalkyl derivatives of curdlan and lichenan

Demleitner, S., Kraus, J. and Franz, Gerhard (1992) Synthesis and antitumour activity of sulfoalkyl derivatives of curdlan and lichenan. Carbohydrate research 226 (2), pp. 247-252.

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Abstract

2-Sulfoethyl, 3-sulfopropyl, and 4-sulfobutyl derivatives of the (1----3)-beta-D-glucan curdlan and the (1----3/1----4)-beta-D-glucan lichenan have been synthesised. The substituents are located mainly at positions 6. The curdlan derivatives strongly inhibited the growth of the Sarcoma 180 tumour, whereas the lichenan derivatives were inactive, indicating that a (1----3)-linked beta-D-glucan backbone is essential for activity.


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Item type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Franz
Identification Number:
ValueType
1617688PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic AgentsMESH
FemaleMESH
Glucans/pharmacologyMESH
MiceMESH
Sarcoma 180/drug therapyMESH
beta-GlucansMESH
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:22622
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