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The role of PI3K p110gamma in chronic liver injury

URN to cite this document:
urn:nbn:de:bvb:355-epub-227888
Dostert, Karin
Date of publication of this fulltext: 06 Dec 2011 07:37


Abstract (English)

The Phosphatidyl-insitol-3-kinase (PI3K) is a central mediator in many signalling pathways, e.g. in insulin signalling and in proinflammatory signalling via mTOR. Previous studies suggested a critical role of PI3K signalling during hepatic fibrogenesis, however, the role of different PI3K p110 isoforms has not been discriminated. The aim of this project was to assess the expression and function ...

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Translation of the abstract (German)

Die Phosphatidyl-insitol-3-kinase (PI3K) ist ein zentraler Mediator vieler Signalwege wie z.B. dem Insulinsignalweg und der via mTOR vermittelten proinflammatorischen Signaltransduktion. Vorangegangene Studien lassen eine wichtige Rolle der Signaltransduktion via PI3K bei der hepatischen Fibrogenese vermuten, wobei die Rolle einzelner Isoformen der PI3K allerdings nicht untersucht wurde. Ziel ...

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