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Synthesis of laminarin sulfates with anticoagulant activity

Alban, S., Kraus, J. and Franz, Gerhard (1992) Synthesis of laminarin sulfates with anticoagulant activity. Arzneimittel-Forschung 42 (8), pp. 1005-1008.

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Abstract

Laminarin sulfates were synthesized without significant degradation of the genuine laminarin chain using SO3/pyridine complex as a sulfation reagent. 6 derivatives with a degree of sulfation (d.s.) ranging from 0.30 to 2.26 could be obtained. According to methylation analysis the C-6-OH-groups of the glucose molecules were preferentially substituted, followed by the OH-groups at C-2 and C-4. The ...

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Item type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Franz
Identification Number:
ValueType
1418069PubMed ID
Classification:
NotationType
Anticoagulants/pharmacologyMESH
Factor XIIa/antagonists & inhibitorsMESH
Factor Xa/antagonists & inhibitorsMESH
HumansMESH
MethylationMESH
Molecular WeightMESH
Partial Thromboplastin TimeMESH
Polysaccharides/pharmacologyMESH
Sulfates/chemistryMESH
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:22791
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