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Antitumor and Immunological Activity of a ß-(1.3/1.6) Glucan from Glomerella cingulata

Gomaa, K. ; Kraus, J. ; Roßkopf, F. ; Röper, H. ; Franz, Gerhard



Abstract

The in vivo antitumour activity of a beta 1----3/1----6 glucan from the fungus Glomerella cingulata was investigated in vivo. The glucan exhibited a strong inhibition of tumour growth of the allogeneic Sarcoma-180 as well as the syngeneic DBA/2-MC.SC-1 fibrosarcoma with inhibition ratios up to 100%. Against the hormone sensitive Noble-Nb-R prostate carcinoma the glucan alone showed a moderate ...

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